Document Type : Research article
Authors
1
Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523
2
Department of histology and cell biology, Faculty of Medicine, Assiut University, Assiut
3
Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528
4
Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University
5
Department of Animal and poultry behavior and management, Faculty of Veterinary Medicine, South Valley University, Qena 83523
6
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh
7
Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, South Valley University, Qena 83523
8
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, South Valley University, Qena 83523
9
Department of Pharmacology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528, Egypt.
Abstract
Osteoarthritis (OA) is a condition that manifests as cartilage deterioration and subchondral bone sclerosis in the joint tissues. The weight-bearing joint is most severely impacted by OA. According to some research, consuming foods high in copper albumin complex (cu-albumin complex) can help with OA-related joint degeneration and pain relief. The current study's objective to determine how oral administration of the cu-albumin complex as an anti-inflammatory medication affected the development of rat knee osteoarthritis (KOA). Fifty adult albino rats were divided into three groups: negative control untreated (n= 10, no KOA induction); positive untreated control (n= 20, KOA induction); and treated group (n= 20, KOA induction with administration of cu-albumin complex). According to the severity of the clinical symptoms, treated and untreated arthritic groups were equally divided into mild and severe groups (n=10). Monosodium iodoacetate (MIA) was used as intra-articular injection for osteoarthritis induction. Rats were euthanized after a month of the beginning of the experiment, and the joints were examined histopathologically and immunohistochemically. It was indicated that the treatment was effective in reducing KOA severity and in improvement of chondroitin sulfate of the affected cartilages. In conclusion, the structure of the chondroitin sulfate in the knee joint cartilages of KOA-affected rats was modified by the cu-albumin complex.
Keywords
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