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SVU-International Journal of Veterinary Sciences
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Kotob, M., Hussein, A., Abd-Elkareem, M. (2021). Histopathological changes of kidney tissue during aging. SVU-International Journal of Veterinary Sciences, 4(1), 54-65. doi: 10.21608/svu.2021.55868.1092
Mohamed Hosny Abdelhafez Kotob; Ahmed Hussein; Mahmoud Abd-Elkareem. "Histopathological changes of kidney tissue during aging". SVU-International Journal of Veterinary Sciences, 4, 1, 2021, 54-65. doi: 10.21608/svu.2021.55868.1092
Kotob, M., Hussein, A., Abd-Elkareem, M. (2021). 'Histopathological changes of kidney tissue during aging', SVU-International Journal of Veterinary Sciences, 4(1), pp. 54-65. doi: 10.21608/svu.2021.55868.1092
Kotob, M., Hussein, A., Abd-Elkareem, M. Histopathological changes of kidney tissue during aging. SVU-International Journal of Veterinary Sciences, 2021; 4(1): 54-65. doi: 10.21608/svu.2021.55868.1092

Histopathological changes of kidney tissue during aging

Article 6, Volume 4, Issue 1 - Serial Number 7, January 2021, Page 54-65  XML PDF (1.03 MB)
Document Type: Research article
DOI: 10.21608/svu.2021.55868.1092
Authors
Mohamed Hosny Abdelhafez Kotob email 1; Ahmed Hussein2; Mahmoud Abd-Elkareem3
1Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
2Zoology Department, Faculty of Science, Al-Azhar University, Assiut, Egypt
3Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
Abstract
Kidney aging is a normal physiological process associates with various molecular, morphologic and functional changes in the kidney tissues. This work was designed to study microscopically the structural changes in the kidney tissue of aged rats compared to young rats.
Male Sprague–Dawley rats were used 10 young rats (4 months) and 10 aged rats (24 months). Rats were transcardially perfused with 4% paraformaldehyde. The kidneys were post fixed for 24 hours in 4 % PFA then proceeded for normal histopathology and light microscopic examination.

Kidney tissue of aged rats showed serious morphological changes such as; segmental glomerulosclerosis, pericapsular fibrosis, tubulointerstitial fibrosis, perivascular fibrosis, inflammatory cell infiltration, tubular dilatation, intra-tubular cast formation and tubular atrophy. These changes were compared to the normal histological appearance of glomeruli, tubules, interstitium, blood vessels of young rat kidneys. In addition, the kidney tissue of the aged rats showed compensatory glomerular hypertrophy, tubular hyperplasia and endothelial proliferation.

Renal aging involves several degenerative changes in kidney structure and these alterations interfere with the physiologic functions and end with chronic renal failure.
Keywords
Aging; Kidney; Glomerulosclerosis; Tubulointerstitial fibrosis; rats
Main Subjects
Clinical veterinary sciences (Pathology and Clinical pathology).
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