Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model

Document Type : Research article


1 Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523

2 Department of histology and cell biology, Faculty of Medicine, Assiut University

3 Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University

4 Department of Anatomy, Faculty of Veterinary Medicine, South Valley University, Qena 83523

5 1 National Food Safety Authority (NFSA), Aswan Branch, Aswan 81528, Egypt. 2 Ministry of Tourism and Antiquities, Aswan Office, Aswan 81511, Egypt.

6 Surgery department, Aswan University, Aswan

7 Department of Animal Physiology, Faculty of Veterinary Medicine, South Valley University, Qena 83523

8 Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt

9 Department of Cardiovascular Physiology, Faculty of medicine, University of Miyazaki, Miyazaki 8891692, Japan


Osteoarthritis (OA) is a degenerative disorder involving the joint, including cartilage and synovial fluids. Recent studies have sought to find curative therapeutics to decrease the adverse effects of OA and relieve associated pain. Globally, knee osteoarthritis (KOA) is the most common type of arthritis. The present study aimed to evaluate the anti-inflammatory effect copper albumen complex (cu-albumin complex) for the treatment of mono-iodoacetate (MIA)-induced KOA in Albino rats. A total of 50 adult male albino rats were involved and divided as follows; 10 rats were kept normal as negative control; 20 arthritic rats were kept untreated (positive control), and 20 arthritic rats were treated with cu-albumin complex orally for a month. Treated and untreated arthritic rats were divided equally (10 rats each) into mild and severe groups according to the severity of signs. The intra-articular injection of MIA in the right knee joint was used for induction of osteoarthritis. Using Mankin grading score, the results demonstrated that the treated groups had a better histological appearance than the control positive group. Additionally with the exception of a few shrunken chondrocytes, the mildly treated group showed less degenerative alterations and appeared virtually normal. While the severe treated group showed increased cellularity with decreased degenerated chondrocytes. It concluded that balanced copper consumption has a positive impact on the prevention and treatment of KOA.


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