Haematobiochemical Profiles and Oxidative Stress Parameters in Pigs (Sus scrofa domesticus) with Mycoplasma hyopneumoniae infection

Document Type : Research article

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1 Department of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria. PO Box 200005

2 Department of Veterinary Physiology and Biochemistry, University of Ibadan, Ibadan, Nigeria

Abstract

Mycoplasma hyopneumoniae significantly impacts pig health and livelihoods. In this study, we evaluated the effects of Mycoplasma hyopneumoniae infection on haematological, biochemical, and oxidative stress parameters in pigs. Clinical infection was confirmed using a Mycoplasma-specific antibody test kit. Mycoplasma hyopneumoniae antibodies were detected in twelve infected pigs and compared to eight healthy controls. Using standard assays, blood samples were analyzed for haematological, biochemical, and oxidative stress markers. No significant differences (P>0.05) were observed in haematobiochemical parameters between infected and healthy pigs. However, oxidative stress markers such as malondialdehyde (MDA), hydrogen peroxide (H2O2), and nitric oxide were significantly elevated in infected pigs. Enzymatic antioxidants, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST), along with non-enzymatic antioxidants like reduced glutathione (GSH), were significantly decreased. Oxidative stress markers, unlike haematobiochemical parameters, are crucial in the pathogenesis of Mycoplasma hyopneumoniae exposure in pigs and could serve as supportive indicators in evaluating host response during infection.

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