Document Type : Research article
Authors
1
Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt
2
Department of histology and cell biology, Faculty of Medicine, Assiut University, Assiut, Egypt
3
Surgery department, Aswan University, A3Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528 Aswan
4
Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University, Egypt.
5
Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University, Egypt
6
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt
7
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt
8
PhD in Veterinary Clinical Pathology, Qena University Hospital, South Valley University, Qena 83523, Egypt.
9
Medical biochemistry, Faculty of Medicine, Al-azhar University, Cairo, Egypt
Abstract
Knee osteoarthritis (KOA) is a common type of joint degeneration which causes progressive damage of the joint structure and has less therapeutic options. It has been found that oral consumption of Copper Albumin Complex as anti-inflammatory drug has a positive effect on the treatment of joint deterioration. The present study aimed to investigate the effect of oral administration of Copper Albumin Complex (cu-albumin complex) on Lysyl oxidase (LOX) which acts as a protective factor in KOA. Fifty adult albino rats were divided into 3 groups: negative control (10 normal rats); positive control (20 rats with KOA which left without induction treatment); and treated group (20 rats with KOA which treated with administration of copper albumin complex). Treated and untreated arthritic groups were subdivided equally into mild and severe groups (10 rats for each) according to the severity of clinical signs. KOA was induced by intra-articular injection of monosodium iodoacetate (MIA). At the experimental end, the joints were examined histopathologically and immunohistochemically after cervical dislocation of rats. It was observed that the treatment with CU- was effective in reducing disease severity and in improvement of Lysyl oxidase KOA. It was concluded that Copper albumin complex has a positive effect in the improvement of LOX of Knee joint cartilages of rats affected by osteoarthritis (OA).
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